Effect of various catechins on the IL-12p40 production by murine peritoneal macrophages and a macrophage cell line, J774.1.

@article{Ichikawa2004EffectOV,
  title={Effect of various catechins on the IL-12p40 production by murine peritoneal macrophages and a macrophage cell line, J774.1.},
  author={Daiju Ichikawa and Ayako Matsui and Miwa Akasofu Imai and Yoshiko Sonoda and Tadashi Kasahara},
  journal={Biological & pharmaceutical bulletin},
  year={2004},
  volume={27 9},
  pages={1353-8}
}
Interleukin-12 (IL-12) is a heterodimeric cytokine comprising p40 and p35 subunits produced mainly by monocytes and macrophages, and plays an essential role in the regulation of the differentiation of Th1 cells. Green tea polyphenols exhibit potent anti-oxidative activities and anti-inflammatory effects by modulating cytokine production. We investigated the effect of catechins on IL-12p40 production in murine macrophages induced by bacterial lipopolysaccharide (LPS). Pretreatment with several… CONTINUE READING
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