Effect of varenicline on smoking cessation through smoking reduction: a randomized clinical trial.

@article{Ebbert2015EffectOV,
  title={Effect of varenicline on smoking cessation through smoking reduction: a randomized clinical trial.},
  author={Jon O. Ebbert and J. R. Hughes and Robert B. West and Stephen I. Rennard and Cristina I Russ and Thomas D McRae and Joan Treadow and Ching-Ray Yu and Michael P Dutro and Peter W Park},
  journal={JAMA},
  year={2015},
  volume={313 7},
  pages={687-94}
}
IMPORTANCE Some cigarette smokers may not be ready to quit immediately but may be willing to reduce cigarette consumption with the goal of quitting. OBJECTIVE To determine the efficacy and safety of varenicline for increasing smoking abstinence rates through smoking reduction. DESIGN, SETTING, AND PARTICIPANTS Randomized, double-blind, placebo-controlled, multinational clinical trial with a 24-week treatment period and 28-week follow-up conducted between July 2011 and July 2013 at 61… CONTINUE READING