Effect of varenicline on aspects of inhibitory control in smokers

  title={Effect of varenicline on aspects of inhibitory control in smokers},
  author={A. J. Austin and Theodora Duka and Jennifer M. Rusted and Anne Jackson},
RationaleVarenicline, a partial agonist at α4β2 nicotinic receptors (nAChRs) aids smoking cessation by reducing craving. Successful quitting may be associated with greater inhibitory control but the effectiveness of varenicline in this regard is unknown.ObjectivesThis study aimed to investigate the effect of varenicline on aspects of inhibitory control in smokers.MethodsA double-blind, placebo-controlled study investigating the effect of varenicline 1 mg (or matched placebo) in satiated and… 



A Questionnaire Measure of Habitual Alcohol Use

Factor analysis of the measure for 593 college students indicates that the highest loading items on the single factor extracted are those relating to drinking rate, and the weekly amount of wine consumed has the lowest factor loading.

Choosing between Small, Likely Rewards and Large, Unlikely Rewards Activates Inferior and Orbital Prefrontal Cortex

The results suggest that decision making recruits neural activity from multiple regions of the inferior PFC that receive information from a diverse set of cortical and limbic inputs, and that the contribution of the orbitofrontal regions may involve processing changes in reward-related information.

Binge drinking, cognitive performance and mood in a population of young social drinkers.

These results confirm previous findings in binge drinkers and suggest that in a nondependent alcohol-drinking group, differences can be seen in mood and cognitive performance between those that binge drink and those that do not.

Differential Involvement of Glutamatergic Mechanisms in the Cognitive and Subjective Effects of Smoking

The results suggest that glutamatergic mechanisms may have differential involvement in the subjective and cognitive actions of smoking, and further investigations using different ligands are warranted to fully characterize the role of glutamate underlying the consequences of smoking behavior.

A role for glutamate in subjective response to smoking and its action on inhibitory control

These findings provide further evidence of a role for glutamate release in the subjective effects of smoking but not the effects on attention and cognitive flexibility and indicate that glutamate release may also be involved in the effect of smoking on inhibitory control.

The nicotine dependence syndrome scale: a multidimensional measure of nicotine dependence.

  • S. ShiffmanA. WatersM. Hickcox
  • Psychology, Medicine
    Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco
  • 2004
The Nicotine Dependence Syndrome Scale (NDSS) presents a valid multidimensional assessment of nicotine dependence that may expand on current measures, and is established that the test-retest reliability of the subscales was adequate.

Effects of central and peripheral nicotinic blockade on human nicotine discrimination

Results suggest that discriminative stimulus effects of nicotine in humans are mediated at least in part by its central effects, as compared with previous animal studies.

Effects of scopolamine and nicotine on human rapid information processing performance

It is indicated that compounds with opposite effects on central cholinergic pathways produce opposite effect on the performance of a task involving rapid information processing, and are consistent with previous findings from this laboratory.

Aging and Inhibitory Control of Action: Cortico-Subthalamic Connection Strength Predicts Stopping Performance

The integrity of r-IFC white matter is an age-independent predictor of stop-signal reaction time (SSRT) and the integrity of white matter projecting to STN predicts both outright stopping and transient braking of response initiation to buy time for action reprogramming.