Effect of var gene disruption on switching in Plasmodium falciparum.

  title={Effect of var gene disruption on switching in Plasmodium falciparum.},
  author={Paul Horrocks and Robert A. Pinches and Sue A Kyes and Neline Kriek and Sarah H. I. Lee and Z{\'o}e Christodoulou and Chris I Newbold},
  journal={Molecular microbiology},
  volume={45 4},
The molecular mechanisms underpinning switching of variant antigens on the surface of Plasmodium falciparum-infected erythrocytes are poorly understood. We tested the hypothesis that insertional disruption of the A4var gene, one of two var genes located within the subtelomeric region of one end of chromosome 13, would result in a preferential switch in transcription to the adjacent R29var gene upon rosette selection. In this way, we aimed to mimic the preferential transcription of R29var in… CONTINUE READING

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