• Corpus ID: 212584828

Effect of using pectin on lead toxicity

@inproceedings{Dalia2010EffectOU,
  title={Effect of using pectin on lead toxicity},
  author={Dalia and M. M. El-Nahal},
  year={2010}
}

• Dalia, M. El-Nahal
• Published 2010

Lead has many undesired effects on humans and animals, including neurological, behavioral, respiratory, visual, growth retardation, hematological immunological, renal, hepatic. The aim of the present study was to investigate the alterations in biochemical parameters in serum and blood due to lead retention in blood, organs and estimating the role of low and high esterified pectin in alleviating the negative effects of lead. Material and Methods: Sixty male albino rats which were divided into ten groups (6 rats for each). The first group (was fed on basal diet ;normal control). Groups 1,2 and 3 [ which were fed on basal diet and administrated lead acetate (LA) daily once a time for 30 days by gavages at three different concentrations 61.94, 30.97 and 15.49 mg /Kg bw (1/4, 1/8, and 1/16 of lead acetate LD50;positive control]. Groups 4,5 and 6 [were fed on basal diet containing 10% low esterified pectin (LEP, DE 31%) and administered the same LA doses]. Groups 7,8 and 9 [were fed on basal diet containing 10% high esterified pectin (HEP, DE 73.5%) with the administration of the same LA doses]. Results obtained showed that LA significantly induced a decrease in body weight, serum total protein, albumin, globulin, total billirubin, direct billirubin, indirect billirubin, RBCs and WBCs counts, blood haemoglobin (Hb), heamatocrite values (PVC), serum triidothyronine (T3)and thyroxin (T4) levels. In the contrary, alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (AlP), gamma glutamyl transferase (-GT) activities, serum urea, uric acid and creatinine were significantly increased in positive control rat groups. Additionally, treatment of rats with LA led to a considerable increase in accumulation of the metal in the blood, liver, kidney, brain, heart and bones compared with the normal group. LEP and HLP significantly decreased the effect of LA on the tested parameters and level of lead in different organs. Histopathological examination clearly indicated that LEP or HEP eliminated from the harmful effect of LA on liver, kidney and brain tissues. In conclusion, LEP and HLP have beneficial effects which could be able to antagonize lead toxicity. Moreover, LEP was contributed to fast elimination of the lead acetate to blood, organs and bones, whereas HEP removed lesser amount of lead. It could be recommended that LEP has a good effect to bind material of lead and should be incorporated into human food to reduce the hazards toxicity of lead pollution of food and water. [Dalia, M. El-Nahal. Effect of using pectin on lead toxicity Dalia, M. El-Nahal. Journal of American Science 2010;6(12):541-554]. (ISSN: 1545-1003). http://www.americanscience.org.