Effect of urokinase on disseminated intravascular coagulation.

  title={Effect of urokinase on disseminated intravascular coagulation.},
  author={Ysvette V{\'a}squez and Charles H Williams and Robert M. Hardaway},
  journal={Journal of applied physiology},
  volume={85 4},
Our study evaluated the possible therapeutic effect of urokinase in treating the microthrombiotic effects of disseminated intravascular coagulation by assisting the activation of endogenous plasminogen. Twenty-six pigs were anesthetized, intubated, mechanically ventilated, and surgically catheterized. Septic shock was induced in all 26 pigs by an intravenous infusion of heat-killed Escherichia coli. The pigs were divided into two sets of experiments: in experiment 2 (n = 14), one-half received… CONTINUE READING


Publications referenced by this paper.
Showing 1-10 of 19 references

Coagulation disorders in septic shock

View 11 Excerpts
Highly Influenced

Modulators of coagulation. A critical appraisal of their role in sepsis.

Archives of internal medicine • 1992
View 11 Excerpts
Highly Influenced

Physiology of shock and injury

A. E. Baue

Physiology of shock and injury. In: Shock and Resuscitation, edited by E

A. E. Baue
R. Geler. New York: McGraw-Hill, • 1993
View 1 Excerpt

Similar Papers

Loading similar papers…