Effect of urokinase on disseminated intravascular coagulation.

@article{Vsquez1998EffectOU,
  title={Effect of urokinase on disseminated intravascular coagulation.},
  author={Ysvette V{\'a}squez and Charles H Williams and Robert M. Hardaway},
  journal={Journal of applied physiology},
  year={1998},
  volume={85 4},
  pages={1421-8}
}
Our study evaluated the possible therapeutic effect of urokinase in treating the microthrombiotic effects of disseminated intravascular coagulation by assisting the activation of endogenous plasminogen. Twenty-six pigs were anesthetized, intubated, mechanically ventilated, and surgically catheterized. Septic shock was induced in all 26 pigs by an intravenous infusion of heat-killed Escherichia coli. The pigs were divided into two sets of experiments: in experiment 2 (n = 14), one-half received… CONTINUE READING

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