Effect of urapidil on steady-state serum digoxin concentration in healthy subjects


In an open, randomized, two-period change-over study the effect of urapidil, an antihypertensive agent, on steady-state serum digoxin levels was investgated in 12 healthy male volunteers. The subjects were given digoxin 0.25 mg once daily for 4 days to produce a steady-state digoxin level in serum. At the end of that time the subjects received either digoxin monotherapy or digoxin and concomitant treatment with urapidil 60 mg b.d. for a further 4 days. Subsequently the treatments were changed over. The absorption characteristics Cmax and tmax of digoxin were not altered by concomitant urapidil treatment. The geometric mean and nonparametric 95% confidence limits of digoxin relative bioavailability were 97% (93%–103%). Therefore, concomitant administration of urapidil with digoxin treatments did not appear to alter the rate and extent of absorption of the glycoside.

DOI: 10.1007/BF00558231

Cite this paper

@article{Solleder1989EffectOU, title={Effect of urapidil on steady-state serum digoxin concentration in healthy subjects}, author={P. Solleder and R. Haerlin and Wolfgang Wurst and Ingrid Klingmann and Hans Mosberg}, journal={European Journal of Clinical Pharmacology}, year={1989}, volume={37}, pages={193-194} }