Effect of upregulated TLR2 expression from G-CSF-mobilized donor grafts on acute graft-versus-host disease.

@article{Lee2015EffectOU,
  title={Effect of upregulated TLR2 expression from G-CSF-mobilized donor grafts on acute graft-versus-host disease.},
  author={W S Lee and J H Kim and Hae-Jeong Won and Soung-Min Lee and Young-Sill Suh and Young-don Joo and Ji-Young Lee and Won-Hee Jang and Sun-Woo Kang and Mi-Sun Kang and S G Park and Il-Whan Choi and Inhak Choi and Su-Kil Seo},
  journal={International immunopharmacology},
  year={2015},
  volume={29 2},
  pages={488-493}
}
Our previous study demonstrated that G-CSF treatment increased the expression of TLR2 in donor grafts; this contributed to rapid engraftment after allogeneic hematopoietic stem cell transplantation (HSCT) in mice. In the current study, we investigated the effects of upregulated TLR2 expression in G-CSF-mobilized donor grafts on acute graft-versus-host disease (GVHD). We found that TLR2 was highly expressed on myeloid cell populations but not T and B cells from the spleens of G-CSF-treated donor… CONTINUE READING

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