Effect of unloading on type I myosin heavy chain gene regulation in rat soleus muscle.

@article{Giger2005EffectOU,
  title={Effect of unloading on type I myosin heavy chain gene regulation in rat soleus muscle.},
  author={J. Giger and F. Haddad and A. Qin and M. Zeng and K. Baldwin},
  journal={Journal of applied physiology},
  year={2005},
  volume={98 4},
  pages={
          1185-94
        }
}
  • J. Giger, F. Haddad, +2 authors K. Baldwin
  • Published 2005
  • Chemistry, Medicine
  • Journal of applied physiology
  • Slow-twitch soleus, a weight-bearing hindlimb muscle, predominantly expresses the type I myosin heavy chain (MHC) isoform. However, under unloading conditions, a transition in MHC expression occurs from slow type I toward the fast-type isoforms. Transcriptional processes are believed to be involved in this adaptation. To test the hypothesis that the downregulation of MHC1 in soleus muscle following unloading is controlled through cis element(s) in the proximal region of the promoter, the MHC1… CONTINUE READING

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