Effect of unilateral ureteral obstruction and anti-angiotensin II treatment on renal tubule cell apoptosis and interstitial fibrosis in rats.

@article{Radovi2014EffectOU,
  title={Effect of unilateral ureteral obstruction and anti-angiotensin II treatment on renal tubule cell apoptosis and interstitial fibrosis in rats.},
  author={Nikola Radovi{\'c} and Gorana Aralica and Danica Gale{\vs}i{\'c} Ljubanovi{\'c} and Vjekoslav Jele{\vc} and Mladen Kontek},
  journal={Collegium antropologicum},
  year={2014},
  volume={38 2},
  pages={583-8}
}
Unilateral ureteral obstruction (UUO) results in a number of pathophysiological and morphological changes in the renal parenchyma, including interstitial inflammation and fibrosis, apoptotic changes of tubular and interstitial cells. Recent studies have indicated an association between renin-angiotensin system and apoptotic alterations in the kidney after unilateral obstructive nephropathy. In this study, the effect of ACE inhibitors and AT1 receptor antagonists on tubular cell apoptosis and… CONTINUE READING