Effect of uncoupling endothelial nitric oxide synthase on calcium homeostasis in aged porcine endothelial cells.

@article{Perrier2009EffectOU,
  title={Effect of uncoupling endothelial nitric oxide synthase on calcium homeostasis in aged porcine endothelial cells.},
  author={Emeline Perrier and Marie-Pierre Fournet-Bourguignon and Emilie Royere and St{\'e}phanie Molez and H{\'e}l{\`e}ne Reure and Ludovic Lesage and Willy Gosgnach and Yves Michel Frapart and Jean-Luc Boucher and Nicole Villeneuve and J P Vilaine},
  journal={Cardiovascular research},
  year={2009},
  volume={82 1},
  pages={133-42}
}
AIMS The requirement of endothelial NO synthase (NOS3) calcium to produce NO is well described, although the effect of NO on intracellular calcium levels [Ca(2+)](i) is still confusing. Therefore, NO and [Ca(2+)](i) cross-talk were studied in parallel in endothelial cells possessing a functional or a dysfunctional NO pathway. METHODS AND RESULTS Dysfunctional porcine endothelial cells were obtained either in vitro by successive passages or in vivo from regenerated endothelium 1 month after… CONTINUE READING

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