Effect of ultrasound on tissue-type plasminogen activator-induced thrombolysis.

@article{Lauer1992EffectOU,
  title={Effect of ultrasound on tissue-type plasminogen activator-induced thrombolysis.},
  author={Carolyn Lauer and Ryan P. Burge and Douglas B. Tang and Bill Bass and E. G. Raspall Gomez and Barbara Marie Alving},
  journal={Circulation},
  year={1992},
  volume={86 4},
  pages={
          1257-64
        }
}
BACKGROUND The efficacy of fibrinolytic therapy is limited by the small surface area of the clot that is available for the binding of the thrombolytic agent, such as tissue-type plasminogen activator (t-PA). We hypothesized that exposure of the clot to ultrasound during thrombolytic treatment could enhance lysis through perturbation of the thrombus, which would expose additional fibrin binding sites for t-PA. METHODS AND RESULTS Whole human blood clots containing radiolabeled fibrinogen were… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 64 CITATIONS, ESTIMATED 42% COVERAGE

Sonothrombolysis for intraocular fibrin formation in an animal model.

  • Ultrasound in medicine & biology
  • 2009
VIEW 6 EXCERPTS
CITES BACKGROUND & METHODS
HIGHLY INFLUENCED

Microbubble-mediated ultrasound drug-delivery and therapeutic monitoring.

  • Expert opinion on drug delivery
  • 2017
VIEW 1 EXCERPT
CITES RESULTS

Review of Protocols Used in Ultrasound Thrombolysis.

  • Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
  • 2017
VIEW 2 EXCERPTS
CITES METHODS

In Vitro Evaluation of Focused Ultrasound-Enhanced TNK-Tissue Plasminogen Activator-Mediated Thrombolysis.

  • Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
  • 2016

FILTER CITATIONS BY YEAR

1991
2018

CITATION STATISTICS

  • 4 Highly Influenced Citations

References

Publications referenced by this paper.
SHOWING 1-10 OF 24 REFERENCES

Facilitation of rt - PA induced fibrinolysis in vitro by exposure to ultrasound . ( abstract )

PT Onundarson, CW Francis, +3 authors VJ Marder
  • Blood
  • 1991

Thrombolysis by transcutaneous ultrasonic irradiation

K Hamano, T Fujinaga, +5 authors H Furuhata
  • ( abstract ) Circulation
  • 1990

Noninvasive thrombolysis with ultrasound . ( abstract )

S Kudo, H Furuhata, +3 authors T Okamura
  • Circulation
  • 1989

Percu - taneous ultrasonic angioplasty : Initial clinical experience

RJ Siegel, DC Cumberland, RK Myler, TA DonMichael
  • Lancet
  • 1989

Thrombolysis with ultrasound effect

S Kudo
  • Tokyo Jikeikai Med J
  • 1989

Similar Papers

Loading similar papers…