Effect of two weeks' treatment with thioridazine, chlorpromazine, sulpiride and bromazepam, alone or in combination with alcohol, on learning and memory in man

  title={Effect of two weeks' treatment with thioridazine, chlorpromazine, sulpiride and bromazepam, alone or in combination with alcohol, on learning and memory in man},
  author={Raija Liljequist and Markku Linnoila and Mauri J. Mattila and Ilkka Saario and Timo Seppälä},
Forty paid healthy male students participated in two subacute experiments of 6 weeks each. In the first trial 20 of them received bromazepam, thioridazine, and placebo double blind cross over for 2 weeks each, and in the second trial the active agents administered to the other 20 participants were chlorpromazine and sulpiride. The tests used were paired associate learning with nonsense syllables and digit memory span. Before testing the subjects took either an alcoholic or a nonalcoholic bitter… 

Effect of diazepam and chlorpromazine on memory functions in man

SummaryThe effect of a single oral dose of diazepam 10 mg or chlorpromazine 25 mg on memory in man was examined in a double-blind study, each drug being crossed-over against placebo, with 20 subjects

Effect of active metabolites of chlordiazepoxide and diazepam, alone or in combination with alcohol, on psychomotor skills related to driving

It is concluded that diazepam-alcohol interaction on psychomotor skills is mainly due to the parent compound.

Dose‐effect study of levomepromazine on psychomotor and memory tasks in healthy volunteers

The effects of single doses of levomepromazine (3, 6 and 12 mg) on psychomotor skills and memory tasks, as well as haemodynamic and pupil diameter parameters, were assessed in 12 normal volunteers.

The effects of chlorpromazine and lithium on appetitive discrimination learning in the rat

The results of this experiment indicate that neither drug retards the acquisition of appetitive tasks, and CPZ decreased the number of trials required for the difficult task at the highest doses used.

Analysis of the influence of bromazepam on cognitive performance through the visual evoked potential (P300).

Results suggest that the effects of bromazepam (3 mg) on cognitive processes are not apparent, and what seems irrefutable in current literature, bromzepam did not produce evident effects on the behavioral and electrophysiological variables analyzed.

The major transquillizers

Drug Interactions with Benzodiazepines: Epidemiologic Correlates with Other CNS Depressants and In Vitro Correlates with Inhibitors and Inducers of Cytochrome P450 3A4

The benzodiazepines are a class of a relatively large number of drugs that share a common chemical structure and have anxiolytic to sedative action on the central nervous system (CNS). They are

Amnestische Begleitwirkungen nach i.v.-Gabe von Lormetazepam und Flunitrazepam

Beobachtungen von Kugler et al. unterstreichen die Notwendigkeit, im Rahmen der Sicherheitsuberprufung neu entwickelter Psychopharmaka diesen Aspekt besonders zu berucksichtigen.

Impact of amitriptyline on learning and memory

Learning is one of the most important mental functions of humans. It is an adopted change in individual behavior resulting from experience. It relies on acquisition of different kinds of knowledge



Effect of two weeks' treatment with chlorimipramine and nortriptyline, alone or in combination with alcohol, on learning and memory

Nortriptyline enhanced the deleterious effect of alcohol on the ability to learn new material, whereas chlorimipramine antagonized alcohol in this respect, which shifted the dose-response graph for the tyramine effect on systolic blood pressure to the right.

Effect of tricyclic antidepressants and alcohol on psychomotor skills related to driving

It seems as if doxepin and amitriptyline but not nortriptylines or chlorimipramine, in combination with 0.5 gm/kg of alcohol, may be especially dangerous in driving.

Drug effects on psychomotor skills related to driving: Interaction of atropine, glycopyrrhonium and alcohol

  • M. Linnoila
  • Medicine, Psychology
    European Journal of Clinical Pharmacology
  • 2004
Both atropine and glycopyrrhonium shortened reaction time and either left co-ordination unaffected or slightly improved, and the combination of anticholinergics and alcohol further impaired attention whilst leaving reaction times and co-ordinate unaffected.

The amnesic effect of diazepam (Valium).

It is considered that the memory difficulties were not due to serious reduction of level of consciousness but do focus on the input or “consolidation” processes rather than on retrieval.

Drug interaction on psychomotor skills related to driving: Diazepam and alcohol

On their own these drugs either did not affect or even slightly improved the skills measured, but their various combinations definitely impaired the subjects' performances, particularly before the peak levels of blood alcohol were reached.

Effects of mode of management on plasma chlorpromazine in psychiatric patients

The study suggests that schizophrenic patients with negligible plasma levels of chlorpromazine are not likely to improve clinically, and interpatient and intrapatient data suggest that trihexyphenidyl tends to lower plasma Levels of chlor Promazine.

Memory access pathway: role of adrenergic versus cholinergic neurons.

The Effects of Alcohol on Evoked Potentials of Various Parts of the Central Nervous System of the Cat

In a comprehensive review, Kalant (1961) quotes Caspers (1958) who worked on rats and furthered the idea that alcohol exerts its earliest effect at the level of the reticular formation and that changes in electrical cortical activity are secondary to the primary reticular depression.

Drug action on the electrical activity of the hippocampus.

  • C. Stumpf
  • Biology
    International review of neurobiology
  • 1965