Effect of two iron-chelators, desferrioxamine and diethylenetriaminepentaacetic acid, on the development of tolerance to the physical dependence on ethanol in mice.


Physical dependence on ethanol was induced in mice by exposing the animals to increasing concentrations of ethanol vapor for a period of 9 days. The degree of dependence was assessed by subjective scoring of a characteristic behavioral withdrawal syndrome upon cessation of ethanol administration. The daily administration of desferrioxamine (350 mg/kg, i.p… (More)


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