Effect of tunicamycin on the glycosylation of rhodopsin.

  title={Effect of tunicamycin on the glycosylation of rhodopsin.},
  author={J. J. Plantner and L. Poncz and E. L. Kean},
  journal={Archives of biochemistry and biophysics},
  volume={201 2},
  • J. J. Plantner, L. Poncz, E. L. Kean
  • Published 1980
  • Biology, Medicine
  • Archives of biochemistry and biophysics
  • Abstract The incorporation of [3H]glucosamine, [3H]mannose, and [35S]methionine into rhodopsin was investigated in retinas which had been incubated in the presence and absence of the antibiotic, tunicamycin. In its presence, the incorporation of glucosamine was inhibited 70% and mannose, 96% compared to controls. In the presence of tunicamycin the attachment of glucosamine to core-region sites was virtually eliminated. The formation of unglycosylated rhodopsin was also indicated by sodium… CONTINUE READING
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