Effect of troglitazone on cytochrome P450 enzymes in primary cultures of human and rat hepatocytes.

@article{Sahi2000EffectOT,
  title={Effect of troglitazone on cytochrome P450 enzymes in primary cultures of human and rat hepatocytes.},
  author={Jasminder Sahi and Gavin Hamilton and Michael W. Sinz and Scott Barros and Susan M Huang and Lawrence J. Lesko and Edward L. Lecluyse},
  journal={Xenobiotica; the fate of foreign compounds in biological systems},
  year={2000},
  volume={30 3},
  pages={
          273-84
        }
}
1. Troglitazone was the first thiazolidinedione approved for clinical use in the treatment of non-insulin-dependent diabetes mellitus. During clinical investigations of drug-drug interactions with therapeutics (terfenadine and cyclosporine) known to be metabolized by CYP3A4, pharmacokinetic interactions were noted upon troglitazone multiple-dose treatments. The nature of the interactions suggested induction of CYP3A enzymes. 2. Primary cultures of human hepatocytes were used to investigate the… CONTINUE READING

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