Effect of triptolide on reproduction of female lesser bandicoot rat, Bandicota bengalensis

@article{Dhar2014EffectOT,
  title={Effect of triptolide on reproduction of female lesser bandicoot rat, Bandicota bengalensis},
  author={Parul Dhar and Neena Singla},
  journal={Drug and Chemical Toxicology},
  year={2014},
  volume={37},
  pages={448 - 458}
}
Abstract Triptolide has been reported to cause antifertility in male rats and mice. However, studies on female rats have been limited. Present study was aimed to evaluate the effects of triptolide on reproduction of wild female rodent pest species, Bandicota bengalensis. Feeding of bait containing 0.1, 0.15 and 0.2% triptolide for a period of 15 days in bi-choice resulted in per day ingestion of 17.37, 23.54 and 27.49 mg/kg body weight of triptolide, respectively. Examination of vaginal smear… 
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TLDR
The present study suggests the potential of triptolide in reproductive management of Rattus rattus and indicates that the cell stages affected had not recovered fully within the 60 day period following triPTolide withdrawal.
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TLDR
Triptolides, at a dose level that induces complete infertility in the adult rats, has minimal adverse effects on the testes and acts primarily on the epididymal sperm making triptolide an attractive lead as a post-testicular male contraceptive.
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TLDR
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