Effect of trimethoprim on serum creatinine in healthy and chronic renal failure volunteers.

@article{Myre1987EffectOT,
  title={Effect of trimethoprim on serum creatinine in healthy and chronic renal failure volunteers.},
  author={S A Myre and John C McCann and M. Roy First and Robert J. Cluxton},
  journal={Therapeutic drug monitoring},
  year={1987},
  volume={9 2},
  pages={161-5}
}
The effect of trimethoprim (TMP) on serum creatinine concentration (SCr) was studied in 10 healthy (H) subjects and nine subjects with chronic renal failure (CRF). Each volunteer was given TMP 100 mg perorally every 12 h for 10 days followed by a 7-day washout period. SCr was measured colorimetrically immediately before the study (baseline), on day 10 of TMP, and 7 days after TMP had been discontinued. SCr increased an average of 14.8% from baseline during TMP administration in the H volunteers… CONTINUE READING

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