Effect of trimebutine on voltage-activated calcium current in rabbit ileal smooth muscle cells.

@article{Nagasaki1993EffectOT,
  title={Effect of trimebutine on voltage-activated calcium current in rabbit ileal smooth muscle cells.},
  author={Masahumi Nagasaki and Seiichi Komori and Hirotsugu Ohashi},
  journal={British journal of pharmacology},
  year={1993},
  volume={110 1},
  pages={399-403}
}
1. The effect of trimebutine on the voltage-dependent inward Ca2+ current was investigated by the whole-cell voltage-clamp technique in single smooth muscle cells from rabbit ileum. 2. Trimebutine (3-100 microM) reduced the Ca2+ current in a concentration-dependent manner. The inhibitory effect on the Ca2+ current was also dependent on the holding potential. The Ca2+ current after a low holding potential was inhibited to a greater extent than that after a high membrane potential: the IC50… CONTINUE READING