Effect of trimebutine on contractile responses in skinned ileal smooth muscle.

@article{Nagasaki1994EffectOT,
  title={Effect of trimebutine on contractile responses in skinned ileal smooth muscle.},
  author={Masaaki Nagasaki and M. Itagaki and Sei-ichi Komori and Hidenori Ohashi},
  journal={Japanese journal of pharmacology},
  year={1994},
  volume={65 3},
  pages={
          249-55
        }
}
The effects of trimebutine on Ca2+ release and modulation of Ca2+ sensitivity of contractile elements induced by carbachol (CCh) were investigated using a tension measuring method in beta-escin-treated skinned smooth muscle of the longitudinal muscle layer of guinea pig ileum. Trimebutine (10-100 microM) concentration-dependently inhibited tension development brought about by Ca2+ release from intracellular stores induced by CCh (10 microM), but did not affect those induced by inositol 1,4,5… Expand
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