Effect of treatment with interferon-gamma alone in visceral leishmaniasis.

@article{Sundar1995EffectOT,
  title={Effect of treatment with interferon-gamma alone in visceral leishmaniasis.},
  author={Shyam Sundar and Henry W. Murray},
  journal={The Journal of infectious diseases},
  year={1995},
  volume={172 6},
  pages={1627-9}
}
Interferon-gamma (IFN-gamma) enhances the therapeutic response to pentavalent antimony in patients with visceral leishmaniasis. To determine the effect of cytokine immunotherapy alone, 9 patients with kala-azar were treated with IFN-gamma before receiving antimony. After 20 days of IFN-gamma therapy, 4 patients showed no parasitologic response; in the remaining 5 patients, however, splenic aspirate parasite scores declined from 4.2 +/- 0.2 to 1.2 +/- 0.5 (mean +/- SE). These results indicate… CONTINUE READING