Effect of treatment with cholecalciferol on the membrane potential and contractility of aortae from spontaneously hypertensive rats

  title={Effect of treatment with cholecalciferol on the membrane potential and contractility of aortae from spontaneously hypertensive rats},
  author={E G Silva and L{\'u}cia Marques Vianna and Paulo Okuyama and Therezinha B. Paiva},
  journal={British Journal of Pharmacology},
1 The diet of spontaneously hypertensive rats (SHR) and normotensive Wistar rats (NWR) was supplemented with 12.5 μg cholecalciferol per 100 g body weight daily, by gavage, for 4 weeks. 2 The amplitude of the contractile responses of aortic rings from SHR to potassium and adrenaline, which was smaller than in NWR aortae, was increased after treatment with cholecalciferol. No further changes were observed in the responses of NWR and SHR aortae in the presence of 100 nM apamin. 3 The membrane… 
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