Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials

@inproceedings{Emberson2014EffectOT,
  title={Effect of treatment delay, age, and stroke severity on the effects of intravenous thrombolysis with alteplase for acute ischaemic stroke: a meta-analysis of individual patient data from randomised trials},
  author={Jonathan Robert Emberson and Kennedy R. Lees and Patrick D. Lyden and Lisa Blackwell and Gregory W. Albers and Erich Bluhmki and Thomas Brott and Geoff Cohen and Stephen M Davis and Geoffrey Alan Donnan and James C. Grotta and George Howard and Markku Kaste and Masatoshi Koga and R{\"u}diger von Kummer and Maarten Lansberg and Richard I Lindley and Gordon D. Murray and Jean Marc Olivot and Mark William Parsons and Barbara C. Tilley and Danilo S Toni and Kazunori Toyoda and Nils Wahlgren and Joanna M. Wardlaw and William N Whiteley and Gregory John del Zoppo and Colin N. Baigent and Peter Ag Sandercock and Werner Hacke},
  booktitle={The Lancet},
  year={2014}
}
BACKGROUND Alteplase is effective for treatment of acute ischaemic stroke but debate continues about its use after longer times since stroke onset, in older patients, and among patients who have had the least or most severe strokes. We assessed the role of these factors in affecting good stroke outcome in patients given alteplase. METHODS We did a pre-specified meta-analysis of individual patient data from 6756 patients in nine randomised trials comparing alteplase with placebo or open… CONTINUE READING
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