Effect of transient chemically induced colitis on the visceromotor response to mechanical colorectal distension.

@article{Gschossmann2002EffectOT,
  title={Effect of transient chemically induced colitis on the visceromotor response to mechanical colorectal distension.},
  author={J M Gschossmann and Birgit Adam and Tobias Liebregts and Lydia Buenger and Michael Ruwe and Guido G H Gerken and Emeran A. Mayer and Gerald Holtmann},
  journal={European journal of gastroenterology & hepatology},
  year={2002},
  volume={14 10},
  pages={1067-72}
}
BACKGROUND Acute mucosal inflammation may initiate alterations of visceral sensory function. However, experimental studies on the potential effects of a transient inflammation on visceral sensitivity are lacking. METHODS We performed colorectal distensions with a barostat device in fasted, conscious, male Lewis rats (n = 20) and assessed the nociceptive response (visceromotor response; VMR) to tonic colorectal distension (CRD) (60 mmHg/3 min) by abdominal-wall electromyography. Measurements… CONTINUE READING

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