Effect of transgene copy number on survival in the G93A SOD1 transgenic mouse model of ALS.

@article{Alexander2004EffectOT,
  title={Effect of transgene copy number on survival in the G93A SOD1 transgenic mouse model of ALS.},
  author={Guillermo M. Alexander and Kirsten L Erwin and Nathaniel M. Byers and Jeffrey S. Deitch and Brian J. Augelli and Elizabeth P. Blankenhorn and Terry D. Heiman-Patterson},
  journal={Brain research. Molecular brain research},
  year={2004},
  volume={130 1-2},
  pages={7-15}
}
Transgenic mice expressing multiple copies of the G93A mutant form of SOD1 develop motor neuron pathology and clinical symptoms similar to those seen in patients with amyotrophic lateral sclerosis (ALS). The phenotype of these mice is dependent on the number of transgene copies in their genome. Changes in transgene copy number, although rare, can sometimes occur while mating due to intra locus recombination events during meiosis. The objective of this study was to develop a real time… CONTINUE READING

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