Effect of transforming growth factor-beta1 on bone regeneration in critical-sized bone defects after irradiation of host tissues.

OBJECTIVE To determine whether sustained release of transforming growth factor (TGF)-beta1 from a gelatin hydrogel would enhance bone regeneration in critical-sized long-bone defects and overcome inhibitory effects of preoperative irradiation. ANIMALS 24 adult New Zealand White rabbits. PROCEDURE Rabbits were allocated to 2 groups. Twelve rabbits… CONTINUE READING