Effect of transforming growth factor-beta on the insulin-like growth factor-I autocrine/paracrine axis in cultured rat articular chondrocytes.

@article{Tsukazaki1994EffectOT,
  title={Effect of transforming growth factor-beta on the insulin-like growth factor-I autocrine/paracrine axis in cultured rat articular chondrocytes.},
  author={Tomoo Tsukazaki and Toshiro Usa and Toshio Matsumoto and Hiroshi Enomoto and Akira Ohtsuru and Hiroyuki Namba and Koei Iwasaki and Shunichi Yamashita},
  journal={Experimental cell research},
  year={1994},
  volume={215 1},
  pages={9-16}
}
Transforming growth factor-beta (TGF-beta) and insulin-like growth factor-I (IGF-I) are essential anabolic factors in articular cartilage. In this study, we concentrated on the elucidation of TGF-beta interaction with IGF-I on cell growth and differentiation in monolayer articular chondrocytes obtained from 5-week-old rats. TGF-beta (1 ng/ml) and IGF-I (25 ng/ml) stimulated DNA synthesis about 6.5- and 2.1-fold over control values, respectively. When TGF-beta and IGF-I were added in combination… CONTINUE READING