Effect of transcatheter arterial embolization on levels of hypoxia-inducible factor-1alpha in rabbit VX2 liver tumors.

@article{Rhee2007EffectOT,
  title={Effect of transcatheter arterial embolization on levels of hypoxia-inducible factor-1alpha in rabbit VX2 liver tumors.},
  author={Thomas K Rhee and Joseph Yeen Young and Andrew C. Larson and G. Kenneth Haines and Kent T. Sato and Riad A Salem and Mary Frances Mulcahy and Laura Kulik and Tatjana Paunesku and Gayle Woloschak and Reed Ali Omary},
  journal={Journal of vascular and interventional radiology : JVIR},
  year={2007},
  volume={18 5},
  pages={639-45}
}
PURPOSE To test the hypothesis that transcatheter arterial embolization (TAE) of VX2 rabbit liver tumors increases the expression of hypoxia-inducible factor-1alpha (HIF-1alpha), a transcription factor that regulates the expression of pro-angiogenic genes. MATERIALS AND METHODS VX2 tumors were implanted in the livers of eight New Zealand white rabbits. Once tumor growth was seen at T2-weighted turbo spin-echo magnetic resonance (MR) imaging, four of the eight rabbits underwent TAE with 45-150… CONTINUE READING

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