Effect of trans-resveratrol on signal transduction pathways involved in paclitaxel-induced apoptosis in human neuroblastoma SH-SY5Y cells.

@article{Nicolini2003EffectOT,
  title={Effect of trans-resveratrol on signal transduction pathways involved in paclitaxel-induced apoptosis in human neuroblastoma SH-SY5Y cells.},
  author={Gabriella Nicolini and R Rigolio and Arianna Scuteri and Mariarosaria Miloso and D Saccomanno and Guido Cavaletti and Giovanni Tredici},
  journal={Neurochemistry international},
  year={2003},
  volume={42 5},
  pages={419-29}
}
trans-Resveratrol (3,4',5-trihydroxystilbene) is able to significantly reduce paclitaxel-induced apoptosis in the human neuroblastoma (HN) SH-SY5Y cell line, acting on several cellular signaling pathways that are involved in paclitaxel-induced apoptosis. trans-Resveratrol reverses phosphorylation of Bcl-2 induced by paclitaxel and concomitantly blocks Raf-1 phosphorylation, also observed after paclitaxel exposure, thus suggesting that Bcl-2 inactivation may be dependent on the activation of the… CONTINUE READING

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