Effect of training and detraining on monocarboxylate transporter (MCT) 1 and MCT4 in Thoroughbred horses

@article{Kitaoka2011EffectOT,
  title={Effect of training and detraining on monocarboxylate transporter (MCT) 1 and MCT4 in Thoroughbred horses},
  author={Yu Kitaoka and Hiroyuki Masuda and Kazutaka Mukai and Atsushi Hiraga and Tohru Takemasa and Hideo Hatta},
  journal={Experimental Physiology},
  year={2011},
  volume={96}
}
The aim of this study was to investigate the effects of training and detraining on the monocarboxylate transporter (MCT) 1 and MCT4 levels in the gluteus medius muscle of Thoroughbred horses. Twelve Thoroughbred horses were used for the analysis. For 18 weeks, all the horses underwent high‐intensity training (HIT), with running at 90–110% maximal oxygen consumption ( ) for 3 min, 5 days week−1. Thereafter, the horses either underwent detraining for 6 weeks by either 3 min of moderate‐intensity… Expand
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References

SHOWING 1-10 OF 49 REFERENCES
Effects of high-intensity training on monocarboxylate transporters in Thoroughbred horses
TLDR
In Thoroughbreds, although the overall changes in MCT protein after endurance training are small, MCT1 and MCT4 can play important roles in the capacity to sustain maximal exercise. Expand
Effect of high intensity training on anaerobic capacity of middle gluteal muscle in Thoroughbred horses.
TLDR
The high intensity training in this study was effective at increasing glycolytic enzyme activity, indicating the possibility to improve anaerobic capacity, which potentially could contribute greatly to performance in Thoroughbred horses. Expand
Effects of low- and moderate-intensity training on metabolic responses to exercise in thoroughbreds.
TLDR
The activity of CS in muscle increased in the first 5 weeks of training whereas HAD activity was not affected by intensity or duration of training, and blood volume, red cell volume and/orred cell volume/kg were unaffected byintensity orduration of training. Expand
Endurance training, expression, and physiology of LDH, MCT1, and MCT4 in human skeletal muscle.
TLDR
Results support the conclusions that 1) endurance training increases expression of MCT1 in muscle because of insertion of M CT1 into both sarcolemmal and mitochondrial membranes, 2) training has variable effects on sarcolemma-enriched MCT4, and 3) both MCTs participate in the cell-cell lactate shuttle, whereas MCT2 facilitates operation of the intracellular lactate Shuttle. Expand
Effects of prolonged training, overtraining and detraining on skeletal muscle metabolites and enzymes.
TLDR
While muscle [glycogen] prior to exercise was lower in overtrained horses, glycogen utilisation/s was not reduced and it may not, therefore, have caused the reduced run time. Expand
Relationship between skeletal muscle MCT1 and accumulated exercise during voluntary wheel running.
TLDR
It appears that mild exercise training fails to increase MCT4 and that changes in MCT1 are complex, depending not only the accumulated exercise but also on the stage of training. Expand
Early and long-term changes of equine skeletal muscle in response to endurance training and detraining
TLDR
It is indicated that endurance-exercise training induces a reversible transition of MHC composition in equine muscle in the order IIX→IIA→I, which is co-ordinated with changes in the metabolic properties of the muscle. Expand
Effect of high-intensity exercise training on lactate/H+ transport capacity in human skeletal muscle.
TLDR
The present data show that intense exercise training can increase lactate/H+transport capacity in human skeletal muscle as well as improve the ability of the muscle to release lactate and H+ during contractions. Expand
Effects of nandrolone phenylpropionate in the horse: (3) skeletal muscle composition in the exercising animal.
TLDR
There was no increase in the percentage of FTH fibres in the biceps femoris with anaerobic training and the fibre area ratio increased significantly in this muscle, and nandrolone phenylpropionate given in conjunction with the training programme only resulted in changes in 2 of these parameters. Expand
Divergent response of metabolite transport proteins in human skeletal muscle after sprint interval training and detraining.
TLDR
It is concluded that short-term SIT induces rapid increases in skeletal muscle oxidative capacity but has divergent effects on proteins associated with glucose, lactate, and fatty acid transport. Expand
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5
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