Effect of trace metals on phagocytosis by alveolar macrophages.

  title={Effect of trace metals on phagocytosis by alveolar macrophages.},
  author={J A Graham and D E Gardner and Michael D. Waters and David L. Coffin},
  journal={Infection and immunity},
  volume={11 6},
Experiments were performed to measure the effect of trace metals on a vital function of the alveolar macrophage (AM), phagocytosis. Since certain trace metals were found to reduce the viability of AMs, a technique was developed to permit examination of live cells only for phagocytosis. Evidence is presented that Ni(2+) selectively altered the phagocytic activity of AMs at concentrations lower than those which caused cell death. It is further shown that a level of VO(3) (-) that caused extensive… CONTINUE READING

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