Effect of topiramate or carbamazepine on the pharmacokinetics of an oral contraceptive containing norethindrone and ethinyl estradiol in healthy obese and nonobese female subjects.

@article{Doose2003EffectOT,
  title={Effect of topiramate or carbamazepine on the pharmacokinetics of an oral contraceptive containing norethindrone and ethinyl estradiol in healthy obese and nonobese female subjects.},
  author={Dennis R Doose and Shean-Sheng Wang and Mukund Padmanabhan and Stefan Schwabe and David Pokrass Jacobs and Meir Bialer},
  journal={Epilepsia},
  year={2003},
  volume={44 4},
  pages={540-9}
}
PURPOSE To study the pharmacokinetics of a combination oral contraceptive (OC) containing norethindrone and ethinyl estradiol during OC monotherapy, concomitant OC and topiramate (TPM) therapy, and concomitant OC and carbamazepine (CBZ) therapy in order to comparatively evaluate the pharmacokinetic interaction, which may cause contraceptive failure. METHODS This randomized, open-label, five-group study included two 28-day cycles. Five groups of female subjects received oral doses of ORTHO… CONTINUE READING

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