Corpus ID: 41783981

Effect of time of day on reward circuitry. A discussion of Byrne et al. 2017

  title={Effect of time of day on reward circuitry. A discussion of Byrne et al. 2017},
  author={Adam Steel and Cibu Thomas and Chris Ian Baker},
  journal={arXiv: Neurons and Cognition},
Byrne and colleagues present a paper on a timely topic with potentially important results. However, we think that issues in the design and analysis complicate the interpretation and limit the generalizability of the findings. Specifically, the details of the small volume correction used in the primary analysis are not adequately described and, moreover, the results do not appear to be corroborated by the whole-brain analysis. In addition, the follow-up multilevel modeling, which is fundamental… 
Effect of time of day on reward circuitry: Further thoughts on methods, prompted by Steel et al 2018
Key challenges include addressing divergent and convergent validity, addressing non-reward neural variation, and testing for absence of variation in threat-related pathways, preregistration and power analysis to protect against false positives, wider range of fMRI methods, and the parallel collection of behavioural data to illuminate the nature of the reward activation across the day.


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  • D. Hodkinson, O. O'Daly, +5 authors Steven C. R. Williams
  • Psychology, Medicine
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
  • 2014
It is demonstrated that time of the day is important when interpreting resting-state data for the purposes of using fMRI as a tool to measure changes in disease processes or in response to treatment.