Effect of tidal volume and positive end-expiratory pressure on expiratory time constants in experimental lung injury.

@article{Henderson2016EffectOT,
  title={Effect of tidal volume and positive end-expiratory pressure on expiratory time constants in experimental lung injury.},
  author={William Reed Henderson and Paolo B Dominelli and Yannick Molgat-Seon and Rachel Lipson and Donald E G Griesdale and Mypinder S. Sekhon and N T Ayas and Andrew William Sheel},
  journal={Physiological reports},
  year={2016},
  volume={4 5}
}
We utilized a multicompartment model to describe the effects of changes in tidal volume (VT) and positive end-expiratory pressure (PEEP) on lung emptying during passive deflation before and after experimental lung injury. Expiratory time constants (τE) were determined by partitioning the expiratory flow-volume (V˙EV) curve into multiple discrete segments and individually calculating τE for each segment. Under all conditions of PEEP and VT, τE increased throughout expiration both before and… CONTINUE READING

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References

Publications referenced by this paper.
SHOWING 1-10 OF 33 REFERENCES

Stress and strain within the lung.

  • Current opinion in critical care
  • 2012
VIEW 1 EXCERPT