Effect of thyroidectomy on fast and slow muscle fibres of rat gastrocnemius muscle.

Abstract

A combined histochemical, biochemical and electrophoretic study with respect to the enzymes succnic dehydrogenase(SDH), myofibrillar adenosine triphosphatase (m-ATPase), lactate dehydrogenase (LDH) isozymes and myosin light chains was carried out to investigate the response of rat gastrocnemius muscle (medial head). Twelve weeks after thyroidectomy, the results indicated a shift from fast to slow type pattern of LDH isozymes, fibre type transformation from Type II to Type I and a decrease in SDH and m-ATPase activity. The results suggest, possible thyroidal involvement in determining the phenotypic properties of skeletal muscle.

Cite this paper

@article{Vashishta2000EffectOT, title={Effect of thyroidectomy on fast and slow muscle fibres of rat gastrocnemius muscle.}, author={Namrata Vashishta and C. L. Talesara}, journal={Indian journal of experimental biology}, year={2000}, volume={38 6}, pages={575-9} }