Effect of thyroid hormone treatment on responses of the isolated working rat heart.

@article{Marriott1983EffectOT,
  title={Effect of thyroid hormone treatment on responses of the isolated working rat heart.},
  author={Marie Marriott and John Hugh McNeill},
  journal={Canadian journal of physiology and pharmacology},
  year={1983},
  volume={61 11},
  pages={1382-90}
}
Hearts from rats pretreated either with L-triiodothyronine (T3) or with L-thyroxine (T4) exhibited changed function curve characteristics on the working heart apparatus compared with hearts from vehicle-treated rats. There was no supersensitivity of the hyperthyroid myocardium to the inotropic effect of isoproterenol as estimated by pD2 values. There were significant increases in +dP/dt and -dP/dt in hyperthyroid working hearts over the entire range of the function curve. T3 hearts showed much… CONTINUE READING

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