Effect of thyroid hormone binding proteins on insulin receptor binding of B1-thyronine-insulin analogues.

@article{ShojaeeMoradie2004EffectOT,
  title={Effect of thyroid hormone binding proteins on insulin receptor binding of B1-thyronine-insulin analogues.},
  author={Fariba Shojaee-Moradie and Michelle P Y Chan and Micayla A Telfer and Dietrich Brandenburg and Erik Sundermann and Heike Eckey and Jens Kleinjung and Achim Sch{\"u}ttler and Richard H. Jones},
  journal={The Biochemical journal},
  year={2004},
  volume={381 Pt 1},
  pages={
          51-7
        }
}
Certain thyronine-insulin analogues, which form non-covalent complexes with plasma proteins, have been shown to act preferentially in the liver. We hypothesized that this property may be dependent on the ability of the analogue to bind to the insulin receptor without prior dissociation from the binding protein. NaB1-L-thyroxyl-insulin, NaB1-3,3',5'-triiodothyronine-insulin, NaB1-D-thyroxyl-insulin and NaB1-L-thyroxyl-aminolauroyl-insulin were compared with insulin for their capacity to inhibit… 
Hepatoselectivity and the evolution of insulin
TLDR
Hepatoselective insulin analogues have the potential to restore the normal hepatic to peripheral gradient in insulin action and the possible therapeutic potential that such analogues may have over currently available insulin preparations is discussed.
Insulin therapy: current alternatives.

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