Effect of thymidylate synthase (TYMS) gene polymorphisms with methotrexate treatment outcome in south Indian Tamil patients with rheumatoid arthritis

@article{Muralidharan2017EffectOT,
  title={Effect of thymidylate synthase (TYMS) gene polymorphisms with methotrexate treatment outcome in south Indian Tamil patients with rheumatoid arthritis},
  author={Niveditha Muralidharan and Durga Prasanna Misra and Vikramraj K Jain and Vir Singh Negi},
  journal={Clinical Rheumatology},
  year={2017},
  volume={36},
  pages={1253-1259}
}
  • Niveditha Muralidharan, Durga Prasanna Misra, +1 author Vir Singh Negi
  • Published in Clinical Rheumatology 2017
  • Medicine
  • Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease causing joint damage and significant functional impairment. Methotrexate (MTX) remains the mainstay for the treatment of RA. MTX inhibits several enzymes of the folate and nucleotide pathways. Thymidylate synthase (TYMS) is an important enzyme in the de novo pyrimidine pathway responsible for DNA replication. The two common gene polymorphisms analyzed in TYMS are 28-bp tandem repeat polymorphism and a 6-bp insertion/deletion… CONTINUE READING

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