Effect of thrombomodulin on the development of monocrotaline-induced pulmonary hypertension

Abstract

The purpose of the present study was to investigate whether thrombomodulin (TM) prevents the development of pulmonary hypertension (PH) in monocrotaline (MCT)-injected rats. Human recombinant TM (3 mg/kg/2 days) or saline were given to MCT-injected male Sprague–Dawley rats for 19 (n = 14) or 29 (n = 11) days. Control rats (n = 6) were run for 19 days. The… (More)
DOI: 10.1007/s00540-013-1663-z

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