Effect of three non-ionic contrast media on rats and rabbits with regard to renal changes. Interspecies comparison.

@article{Bhargava1990EffectOT,
  title={Effect of three non-ionic contrast media on rats and rabbits with regard to renal changes. Interspecies comparison.},
  author={Aruna Bhargava and Rudolf J. Hofmeister and Fred Siegmund and Carsten Sch{\"o}bel and Peter Guenzel},
  journal={Arzneimittel-Forschung},
  year={1990},
  volume={40 7},
  pages={
          822-9
        }
}
The effect of three non-ionic contrast media (iosimide, iopamidol and iopromide) was investigated in rabbits and rats after single i.v. application up to high doses with regard to renal changes. Determinations of serum urea nitrogen and creatinine and urinary enzymes (lactate dehydrogenase, gamma-glutamyl-transpeptidase and N-acetyl-beta-D-glucosaminidase) as well as histological examinations of the kidneys were performed. The results obtained demonstrate that rabbit as an experimental animal… CONTINUE READING