Effect of thiol pendant conjugates on plasmid DNA binding, release, and stability of polymeric delivery vectors.

Abstract

Polymers have attracted much attention as potential gene delivery vectors due to their chemical and structural versatility. However, several challenges associated with polymeric carriers, including low transfection efficiencies, insufficient cargo release, and high cytotoxicity levels have prevented clinical implementation. Strong electrostatic interactions… (More)
DOI: 10.1021/bm3004786

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Cite this paper

@article{Bacalocostantis2012EffectOT, title={Effect of thiol pendant conjugates on plasmid DNA binding, release, and stability of polymeric delivery vectors.}, author={Irene Bacalocostantis and Viraj P. Mane and Michael S Kang and Addison S. Goodley and Silvia Muro and Peter Kofinas}, journal={Biomacromolecules}, year={2012}, volume={13 5}, pages={1331-9} }