Effect of thioacetamide, growth hormone or partial hepatectomy on spermidine acetylase activity of rat liver cytosol.

Abstract

Rat liver cytosol extracts catalyzed the formation of monoacetylspermidine when incubated with acetyl-CoA and spermidine. This activity was enhanced 15-fold by administration of thioacetamide (150 mg/kg). The peak of activity occurred 18-24 h after treatment with the drug and then declined reaching control levels by 76 h. Previous studies have shown that… (More)

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