Effect of thiazolidinediones on bile acid transport in rat liver.

  title={Effect of thiazolidinediones on bile acid transport in rat liver.},
  author={Kris L Snow and Richard H. Moseley},
  journal={Life sciences},
  volume={80 8},
The thiazolidinedione derivatives, troglitazone, rosiglitazone, and pioglitazone, are novel insulin-sensitizing drugs that are useful in the treatment of type 2 diabetes. However, hepatotoxicity associated with troglitazone led to its withdrawal from the market in March 2000. In view of case reports of hepatotoxicity from rosiglitazone and pioglitazone, it is unclear whether thiazolidinediones as a class are associated with hepatotoxicity. Although the mechanism of troglitazone-associated… CONTINUE READING


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