Effect of therapeutic interventions on oxidized phospholipids on apolipoprotein B100 and lipoprotein(a).

@article{Yeang2016EffectOT,
  title={Effect of therapeutic interventions on oxidized phospholipids on apolipoprotein B100 and lipoprotein(a).},
  author={Calvin Yeang and Ming-yow Hung and Young-Sup Byun and Paul C Clopton and Xing Guang John Yang and Joseph L. Witztum and Sotirios Tsimikas},
  journal={Journal of clinical lipidology},
  year={2016},
  volume={10 3},
  pages={
          594-603
        }
}
BACKGROUND Oxidized phospholipids (OxPL) on apolipoprotein B-100 (OxPL-apoB) reflect the biological activity of lipoprotein(a) (Lp[a]) and predict cardiovascular disease events. However, studies with statins and low-fat diets show increases in OxPL-apoB and Lp(a). OBJECTIVE This study evaluated changes in OxPL-apoB and Lp(a) with extended-release niacin (N), ezetimibe/simvastatin (E/S) and combination E/S/N. A systematic literature review of previously published trials, measuring both OxPL… CONTINUE READING
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