Effect of theophylline on membrane potential and contractile force in hamster diaphragm muscle in vitro.

  • S A Esau
  • Published 1986 in The Journal of clinical investigation


Theophylline enhances the force of diaphragmatic contraction and delays fatigue. The mechanism is not known, but recent evidence suggests it may act at the cell membrane. To test this hypothesis, we studied the effect of theophylline on resting membrane potential and tension in hamster diaphragm cells. Muscle strips were obtained from five adult hamsters… (More)


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