Effect of the uncharged imidazolium moiety in adenine on endothelium-independent relaxation in the contracted thoracic aorta of Sprague-Dawley rats.

Abstract

Adenine had a concentration-dependent relaxation action on the phenylephrine-contracted aorta ring, with an EC(50) value of 0.40±0.12 mM. This effect was also observed in the endothelium-denuded aorta. Among the adenine analogues, N-methyladenine and benzimidazole still evoked an apparent relaxation effect, while 1-, 3- or 7-methyladenine and imidazole were… (More)

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@article{Tokuda2012EffectOT, title={Effect of the uncharged imidazolium moiety in adenine on endothelium-independent relaxation in the contracted thoracic aorta of Sprague-Dawley rats.}, author={Shinji Tokuda and Toshihiko Fukuda and Yutaro Kobayashi and Mitsuru Tanaka and Toshiro Matsui}, journal={Bioscience, biotechnology, and biochemistry}, year={2012}, volume={76 4}, pages={828-30} }