Corpus ID: 10926686

Effect of the trichothecene mycotoxin diacetoxyscirpenol on nitrosamine-induced oesophageal cancer and on relevant enzymes in oesophagus and liver.

@article{Craddock1987EffectOT,
  title={Effect of the trichothecene mycotoxin diacetoxyscirpenol on nitrosamine-induced oesophageal cancer and on relevant enzymes in oesophagus and liver.},
  author={V. M. Craddock},
  journal={IARC scientific publications},
  year={1987},
  volume={84},
  pages={
          266-9
        }
}
  • V. M. Craddock
  • Published 1987
  • Medicine
  • IARC scientific publications
  • To test the concept that human oesophageal cancer is initiated by nitrosamines and potentiated by consumption of food contaminated by mycotoxins produced by Fusaria, the effect of the trichothecene mycotoxin diacetoxyscirpenol (DS), alone and in combination with N-nitroso-N-methylbenzylamine (NMBzA), on rat oesophagus was studied. Chronic treatment with DS induced oesophageal hyperplasia, but simultaneous treatment with NMBzA tended to inhibit rather than to enhance carcinogenesis. The… CONTINUE READING