Effect of the substitutions in the alpha helix and the beta sheet of HLA class I molecule on allorecognition of T cells specific for HLA-B51 and HLA-Bw53.

@article{Hiraiwa1992EffectOT,
  title={Effect of the substitutions in the alpha helix and the beta sheet of HLA class I molecule on allorecognition of T cells specific for HLA-B51 and HLA-Bw53.},
  author={Masaki Hiraiwa and Ikuko Nishimura and Noriko Kato and Takeshi Nagao and Kyoichi Kano and Masafumi Takiguchi},
  journal={Human immunology},
  year={1992},
  volume={33 2},
  pages={82-8}
}
HLA-B51 and HLA-Bw53 differ by eight amino acids on the alpha 2 domain. Of these eight amino acid substitutions, two are in the alpha helix and six are in the beta sheet. The effect of these substitutions on allorecognition of HLA-B51-specific cytotoxic T lymphocyte (CTL) clones and HLA-Bw53-specific CTL clones was investigated using chimeric antigen (Ag… CONTINUE READING