Effect of the selective 5-HT7 receptor antagonist SB 269970 in animal models of anxiety and depression

  title={Effect of the selective 5-HT7 receptor antagonist SB 269970 in animal models of anxiety and depression},
  author={Anna Wesołowska and Agnieszka Nikiforuk and Katarzyna Stachowicz and Ewa Tatarczyńska},

Effects of SB-269970, a 5-HT7 receptor antagonist, in mouse models predictive of antipsychotic-like activity

Results indicate that blockade of 5-HT7 receptors partially modulates glutamatergic and dopaminergic function and could be clinically useful for the treatment of positive symptoms of schizophrenia.

Influence of serotonin 5-HT(7) receptor blockade on the behavioral and neurochemical effects of imipramine in rats.

Findings suggest that the increase in cortical NA level seems to account for the anti-immobility action observed after joint administration of the selective 5-HT(7) receptor antagonist and imipramine in rats.

Role of 5-HT7 receptors in the anxiety-like behavior in naloxone-induced withdrawal symptoms in mice

The results showed that there were no significant differences in the number of entries into the open arms and the time spent in open areas of plus-maze between the experimental groups, and the 5-HT7 receptor had no significant role in the anxiety behavior related to morphine withdrawal.

Effects of the Selective 5-HT7 Receptor Antagonist SB-269970 and Amisulpride on Ketamine-Induced Schizophrenia-like Deficits in Rats

In conclusion, antagonism of 5-HT7 receptors may represent a useful pharmacological approach in the treatment of cognitive deficits and some negative symptoms of schizophrenia.

Antidepressant-like effects of a novel 5-HT3 receptor antagonist 6z in acute and chronic murine models of depression

6z is a novel 5-HT3 receptor antagonist with potential antidepressant-like activities, which may be related to modulating hypothalamic-pituitary-adrenal axis and attenuating brain oxidative damage.

The 5-HT7 receptor as a mediator and modulator of antidepressant-like behavior




Role of the serotonergic system in the forced swimming test

  • F. Borsini
  • Biology, Psychology
    Neuroscience & Biobehavioral Reviews
  • 1995

No hypothermic response to serotonin in 5-HT7 receptor knockout mice

The results show that 5-HT-induced hypothermia is mediated by the 5- HT7 receptor, and that oleamide may act through an independent mechanism as well as at an allosteric5-HT7 receptor site to regulate body temperature.