Effect of the selective 5-HT7 receptor antagonist SB 269970 in animal models of anxiety and depression

  title={Effect of the selective 5-HT7 receptor antagonist SB 269970 in animal models of anxiety and depression},
  author={A. Wesołowska and A. Nikiforuk and K. Stachowicz and E. Tatarczyńska},
  • A. Wesołowska, A. Nikiforuk, +1 author E. Tatarczyńska
  • Published 2006
  • Chemistry, Medicine
  • Neuropharmacology
  • The aim of the present study was to examine the effect of the selective 5-HT7 receptor antagonist SB 269970 (0.25-20 mg/kg) in the behavioral tests commonly used for predicting anxiolytic- and antidepressant-like activity. Diazepam and imipramine were used as standard drugs. SB 269970 (in one medium dose of 0.5 or 1 mg/kg) exerted a specific antianxiety-like effect in the Vogel drinking test in rats, in the elevated plus-maze test in rats and in the four-plate test in mice. Moreover, SB 269970… CONTINUE READING
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