Effect of the recombinant vaccinia viruses that express HTLV-I envelope gene on HTLV-I infection.

@article{Shida1987EffectOT,
  title={Effect of the recombinant vaccinia viruses that express HTLV-I envelope gene on HTLV-I infection.},
  author={Hisatoshi Shida and T Tochikura and Taka Aki Sato and Toshihiro Konno and Kazunori Hirayoshi and Makoto Seki and Yasuhiko Ito and Masakazu Hatanaka and Yorio Hinuma and Masanobu Sugimoto},
  journal={The EMBO journal},
  year={1987},
  volume={6 11},
  pages={3379-84}
}
The human T-lymphotropic virus type I (HTLV-I) is etiologically linked to adult T-cell leukemia (ATL). To develop a vaccine against ATL, we constructed recombinant vaccinia viruses containing the envelope gene of HTLV-I in the vaccinia virus hemagglutinin (HA) gene, a new site where foreign genes can be inserted. A single inoculation of the recombinant virus induced antibodies to the env proteins of HTLV-I in rabbits and had a protective effect against HTLV-I infection.